Metabotropic glutamate 5 receptor (mglur5)
-Computer-generated model of a specific receptor with details on binding, structure-function relationship etc
Roughly 800 words on the specific receptor
specific receptor, you will need to generate a model of the Metabotropic glutamate 5 receptor (mglur5) receptor. While generating the model, you will need to make notes on what you did and annotate the model to provide functional detail related to its structure. You will also choose a protein that partners (interacts with) the chosen receptor (note that this must be an endogenous ligand, not a drug because there is a separate discussion on drugs, see below).
Metabotropic glutamate 5 receptor (mglur5), you will need to discuss:
-its function(s), -any relevant role(s) in the physiology and in the pathophysiology of diseases, -the details of the receptors structure with particular attention to the details of binding and signalling and how the structure relates to the function.
-Additionally, discuss a drug that binds to that receptor, if applicable (for example, a calcium channel blocker), and briefly explain the mechanisms and therapeutic use. If there are no drugs available to bind the receptor, please make this point very clear and explain if there are alternative ways by which the receptor can be involved in therapeutic function(s).
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